All Friday DSCB Journal Club videos recorded from Zoom during the pandemic are uploaded here after the end of the presentations.
Friday, October 1, 2021 - Noon - 1:00PM - Room: Zoom
Dan Wagner, Ph.D. (Faculty)
“Clonal bottlenecks in early human embryonic development”
Park, Seongyeol, Nanda Maya Mali, Ryul Kim, Jeong-Woo Choi, Junehawk Lee, Joonoh Lim, Jung Min Park, et al. 2021. “Clonal Dynamics in Early Human Embryogenesis Inferred from Somatic Mutation.” Nature 597 (7876): 393–97.
Bonnie Zhu (Student)
"Cell competition: barrier for interspecies chimerism".
Canbin Zheng, Yingying Hu, Masahiro Sakurai, et al. Cell competition constitutes a barrier for interspecies chimerism. Nature volume 592, pages 272–276 (2021) https://www.nature.com/articles/s41586-021-03273-0
Coaches: Dan Wagner, Ph.D. and Bjoern Schwer, M.D., Ph.D.
View Recording:
Friday, June 4, 2021 - 12:00pm - 1:00pm - Room: Zoom
Emily Wolfgram (student)
"Regulation of oogenesis by the myoepithelium in the Drosophila ovary"
Weaver LN, Drummond-Barbosa D. Hormone receptor 4 is required in muscles and distinct ovarian cell types to regulate specific steps of Drosophila oogenesis. Development. 2021 Mar 9;148(5):dev198663. doi: 10.1242/dev.198663. PMID: 33547134; PMCID: PMC7970067.
Coaches: Todd Nystul and Diana Laird
View Recording:
Friday, May 14, 2021 - 12:00pm - 1:00pm - Room: Zoom
Haley Smith (student)
"Shapeshifting from an oval to a cup: mouse epiblast morphogenesis"
Weberling A, Zernicka-Goetz M. Trophectoderm mechanics direct epiblast shape upon embryo implantation. Cell Rep. 2021 Jan 19;34(3):108655. doi: 10.1016/j.celrep.2020.108655. PMID: 33472064; PMCID: PMC7816124.
Coaches: Daniel Wagner and Robert Blelloch
Irena Roy (student)
"Defying Waddington's landscape: in vivo reprogramming of cranial neural crest"
Zalc A, Sinha R, Gunsagar G, Wesche D, Daszczuk P, Swigot T, Weissman I, Wysocka J, et al. Reactivation of the pluripotency program precedes formation of the cranial neural crest. Science 2021; 371(6529). doi: 20.1126/science.abb4776
Coaches: Faranak Fattahi and Licia Selleri
View Recording:
Friday, April 16, 2021 - 12:00pm - 1:00pm - Room: Zoom
Ali Kalantari (student)
"Having a blast with stem cells: blastocyst-like structures made from hPSCs"
Yu, L., Wei, Y., Duan, J. et al. Blastocyst-like structures generated from human pluripotent stem cells. Nature 591, 620–626 (2021). https://doi.org/10.1038/s41586-021-03356-y
Coaches: Barbara Panning and Aaron Tward
Bonnie Zhu (student)
"Gpr161 ciliary pools prevent hedgehog pathway hyperactivation phenotypes specifically from lack of Gli transcriptional repression."
Sun-Hee Hwang, Bandarigoda N. Somatilaka, Kevin White, Saikat Mukhopadhyay. Gpr161 ciliary pools prevent hedgehog pathway hyperactivation phenotypes specifically from lack of Gli transcriptional repression. bioRxiv 2021. doi: https://doi.org/10.1101/2021.01.07.425654
Coaches: Thomas Nowakowski and Jeremy Reiter
View Recording:
Friday, March 19, 2021 - 12:00pm - 1:00pm - Room: Zoom
Christopher Chen (student)
"Scales use waves to scale"
De Simone, A., Evanitsky, M.N., Hayden, L. et al. Control of osteoblast regeneration by a train of Erk activity waves. Nature 590, 129–133 (2021). https://doi.org/10.1038/s41586-020-03085-8
Coaches: Guo Huang and Dan Wagner
Angeline Chemel (student)
"The Enteric Nervous System can regenerate?"
The enteric nervous system in zebrafish larvae can regenerate via migration into the ablated area and proliferation of neural crest-derived cells Maria Ohno1,*, Masataka Nikaido1,*, Natsumi Horiuchi2 , Koichi Kawakami3 and Kohei Hatta1, Development (2021) 148, dev195339
Coaches: Faranak Fattahi and Guo Huang
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Friday, February 19, 2021 - 12:00pm - 1:00pm - Room: Zoom
Dan Wagner (faculty)
"Gene pairing as a genomic strategy for coordinating oscillatory gene expression during somitogenesis."
Zinani, Oriana Q. H., Kemal Keseroğlu, Ahmet Ay, and Ertuğrul M. Özbudak. 2021. “Pairing of Segmentation Clock Genes Drives Robust Pattern Formation.” Nature 589 (7842): 431–36.
Elena Turkalj (student)
"Cellular diversity, niche cues, and the developing human intestine."
Holloway EM, Czerwinski M, Tsai YH, Wu JH, Wu A, Childs CJ, Walton KD, Sweet CW, Yu Q, Glass I, Treutlein B, Camp JG, Spence JR. Mapping Development of the Human Intestinal Niche at Single-Cell Resolution. Cell Stem Cell. 2020 Nov 25:S1934-5909(20)30546-4. doi: 10.1016/j.stem.2020.11.008. Epub ahead of print. PMID: 33278341.
Coaches: Dan Wagner and Brian Feldman
View Recording:
Friday, November 13, 2020 - 12:00pm - 1:00pm - Room: Zoom
Elliott Sherr (faculty)
“3D excitement!!”
Neuronal defects in a human cellular model of 22q11.2 deletion syndrome:
Khan, T.A., Revah, O., Gordon, A. et al. Neuronal defects in a human cellular model of 22q11.2 deletion syndrome. Nat Med (2020). https://doi.org/10.1038/s41591-020-1043-9
Karissa Hansen (student)
"Disentangling Polycomb-mediated transcriptional repression."
Dobrinić P, Szczurek AT, and Klose RJ. PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency. bioRxiv 2020. doi: https://doi.org/10.1101/2020.10.09.333294
Coaches: Barbara Panning and Robert Blelloch
View Recording:
Friday, October 23, 2020 - 12:00pm - 1:00pm - Room:
Guo Huang (faculty)
"Gold Mining Between Two Fish"
Wang W, Hu SK, Zeng A, Alegre D; Hu D, Gotting K, Ortega Granillo A, Wang Y, Robb S, Schnittker R, Zhang S, Alegre D, Li H, Ross E, Zhang N; Brunet A, Sánchez Alvarado A. 2020. Changes in Regeneration-Responsive Enhancers Shape Regenerative Capacities in Vertebrates. Science 369 (6508): eaaz3090.
Aris Taychameekiatchai (student)
“Who WIHNs in post-injury hair follicle neogenesis?”
Abbasi, S. et al. Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing. Cell Stem Cell 27, 396-412.e6 (2020).
Coaches: Saul Villeda and Bruce Wang
View Recording:
Friday, October 2, 2020 - 12:00pm - 1:00pm - Room: Zoom
Sam Pleasure (faculty)
"How to tame PANDAS"
Xu J, Liu RJ, Fahey S, et al. Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity. The American Journal of Psychiatry. 2020 Jun:appiajp202019070698. DOI: 10.1176/appi.ajp.2020.19070698.
Reed McMullen (student)
"Organoid Brain Washing"
Pellegrini L, Bonfio C, Chadwick J, Begum F, Skehel M, Lancaster MA. Human CNS barrier-forming organoids with cerebrospinal fluid production. Science. 2020;369(6500):eaaz5626. doi:10.1126/science.aaz5626
Coaches: Deepak Lamba and Saul Villeda
View Recording:
Friday, June 5, 2020 - 12:00pm - 1:00pm
Aris Taychameekiatchai (student)
"Differences in biosynthetic production define potency hierarchy in colorectal cancer"
Morral et al., Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer, Cell Stem Cell (2020), https://doi.org/10.1016/j.stem.2020.04.012
Coaches: Todd Nystul and Barbara Panning
Karissa Hansen (student)
“Dynamic regulation at the Hoxd locus in the development of external genitalia”
Amândio, A. R., Lopez-Delisle, L., Bolt, C. C., Mascrez, B., & Duboule, D. (2020). A complex regulatory landscape involved in the development of mammalian external genitals. eLife, 9, e52962. https://doi.org/10.7554/eLife.52962
Coaches: Nadav Ahituv and Yin Shen
View Recording: https://dscbintranet.ucsf.edu/file/216
Friday, May 15, 2020 - 12:00pm - 1:00pm
Eliza Gaylord (student)
"Organoids Develop Motor Skills: Self-Organizing 3D Human Trunk Neuromuscular Organoids."
Faustino Martins et al., Self-Organizing 3D Human Trunk Neuromuscular Organoids, Cell Stem Cell (2019), https://doi.org/10.1016/j.stem.2019.12.007
Coaches: Faranak Fattahi and Andrew Brack
Reed McMullen (student)
"Scale-ing epithelial organoids"
Yorick Post et al., Snake Venom Gland Organoids, Cell (2020), https://doi.org/10.1016/j.cell.2019.11.038
Coaches: Todd McDevitt and Ophir Klein
View Recording: https://dscbintranet.ucsf.edu/file/206
Friday, April 17, 2020 - 12:00pm - 1:00pm
Gugene Kang (student)
"Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouse."
Bakken et al., Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouse. doi: https://doi.org/10.1101/2020.03.31.016972.
Coaches: Michael Oldham and Alex Pollen
Alexander Merriman (student)
"Comprehensive In Vivo Interrogation Reveals Phenotypic Impact of Human Enhancer Variants."
Kvon, E. Z., Zhu, Y., Kelman, G., Novak, C. S., Plajzer-Frick, I., Kato, M., Garvin, T. H., Pham, Q., Harrington, A. N., Hunter, R. D., Godoy, J., Meky, E. M., Akiyama, J. A., Afzal, V., Tran, S., Escande, F., Gilbert-Dussardier, B., Jean-Marçais, N., Hudaiberdiev, S., … Pennacchio, L. A. (2020). Comprehensive In Vivo Interrogation Reveals Phenotypic Impact of Human Enhancer Variants. Cell, 180(6), 1262–1271.e15. https://doi.org/10.1016/j.cell.2020.02.031
Coaches: Jeff Bush
View Recording: https://dscbintranet.ucsf.edu/file/186
Friday, March 20, 2020 - 12:00pm - 1:00pm
Thi Nguyen (student)
"Vertebrate diapause preserves organisms long term through Polycomb complex members"
Hu, Chi-Kuo, et al. "Vertebrate diapause preserves organisms long term through Polycomb complex members." Science 367.6480 (2020): 870-874.
Coaches: Todd Nystul and Guo Huang
Emily Bulger (student)
"Axial patterning in vitro: Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids."
Van den Brink, S.C., Alemany, A., van Batenburg, V. et al. Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids. Nature (2020). https://doi.org/10.1038/s41586-020-2024-3
Faculty coaches: Licia Selleri and Georgia Panagiotankos
Video Recording: https://dscbintranet.ucsf.edu/file/181